Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration-Reference-Cited by-同舟云学术

Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration

Author:

Liu Qinfang¹²^ORCID,Bautista-Gomez Judith³^ORCID,Higgins Daniel A.³,Yu Jianzhong²⁴^ORCID,Xiong Yulan¹²^ORCID

Affiliation:

1. Department of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06030, USA.

2. Department of Anatomy and Physiology, Kansas State University College of Veterinary Medicine, Manhattan, KS 66506, USA.

3. Department of Chemistry, Kansas State University, Manhattan, KS 66506, USA.

4. Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.

Abstract

Clathrin-mediated endocytosis in neurons is sensitive to the abundance and activity of the kinase LRRK2.

Funder

National Institute on Aging

National Institute of General Medical Sciences

National Institute of Neurological Disorders and Stroke

American Parkinson Disease Association

University of Connecticut

Parkinsonfonden

College of Veterinary Medicine, Kansas State University

Parkinson’s Foundation

Kansas State University College of Veterinary Medicine

This

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference62 articles.

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