The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease

Author:

Bandres‐Ciga Sara12,Saez‐Atienzar Sara3,Bonet‐Ponce Luis4,Billingsley Kimberley156,Vitale Dan7,Blauwendraat Cornelis1,Gibbs Jesse Raphael7,Pihlstrøm Lasse8,Gan‐Or Ziv910ORCID,Noyce Alastair J,Kaiyrzhanov Rauan,Middlehurst Ben,Kia Demis A,Tan Manuela,Houlden Henry,Morris Huw R,Plun‐Favreau Helene,Holmans Peter,Hardy John,Trabzuni Daniah,Bras Jose,Quinn John,Mok Kin Y,Kinghorn Kerri J.,Billingsley Kimberley,Wood Nicholas W,Lewis Patrick,Schreglmann Sebastian,Guerreiro Rita,Lovering Ruth,RņBibo Lea,Manzoni Claudia,Rizig Mie,Ryten Mina,Guelfi Sebastian,Escott‐Price Valentina,Chelban Viorica,Foltynie Thomas,Williams Nigel,Morrison Karen E.,Brice Alexis,Danjou Fabrice,Lesage Suzanne,Corvol Jean‐Christophe,Martinez Maria,Schulte Claudia,Brockmann Kathrin,SimɃn‐Sȥnchez Javier,Heutink Peter,Rizzu Patrizia,Sharma Manu,Gasser Thomas,Nicolas Aude,Cookson Mark R,Bandres‐Ciga Sara,Blauwendraat Cornelis,Craig David W.,Faghri Faraz,Gibbs J Raphael,Hernandez Dena G.,Van Keuren‐Jensen Kendall,Shulman Joshua M.,Iwaki Hirotaka,Leonard Hampton L.,Nalls Mike A.,Robak Laurie,Lubbe Steven,Finkbeiner Steven,Mencacci Niccolo E.,Lungu Codrin,Singleton Andrew B,Scholz Sonja W.,Reed Xylena,Alcalay Roy N.,Gan‐Or Ziv,Rouleau Guy A.,Hilten Jacobus J,Marinus Johan,Adarmes‐GɃmez Astrid D.,Aguilar Miquel,Alvarez Ignacio,Alvarez Victoria,Barrero Francisco Javier,Yarza Jesɐs Alberto Bergareche,Bernal‐Bernal Inmaculada,Blazquez Marta,Bonilla‐Toribio Marta,Botȷa Juan A.,Boungiorno Marȷa Teresa,Buiza‐Rueda Dolores,Cȥmara Ana,Carrillo Fȥtima,CarriɃn‐Claro Mario,Cerdan Debora,ClarimɃn Jordi,Compta Yaroslau,Casa Beatrȷz,Diez‐Fairen Monica,Dols‐Icardo Oriol,Duarte Jacinto,Duran Raquel,Escamilla‐Sevilla Francisco,Ezquerra Mario,Feliz Cici,Fernȥndez Manel,Fernȥndez‐Santiago Rubȳn,Garcia Ciara,Garcȷa‐Ruiz Pedro,GɃmez‐Garre Pilar,Heredia Maria Jose Gomez,Gonzalez‐Aramburu Isabel,Pagola Ana Gorostidi,Hoenicka Janet,Infante Jon,Jesús Silvia,Jimenez‐Escrig Adriano,Kulisevsky Jaime,Labrador‐Espinosa Miguel A.,Lopez‐Sendon Jose Luis,Munain Arregui Adolfo LɃpez,Macias Daniel,Torres Irene Martȷnez,Marȷn Juan,Marti Maria Jose,Martȷnez‐Castrillo Juan Carlos,Mȳndez‐del‐Barrio Carlota,Gonzȥlez Manuel Menȳndez,Mata Marina,Mȷnguez Adolfo,Mir Pablo,Rezola Elisabet Mondragon,MuɁoz Esteban,Pagonabarraga Javier,Pascual‐Sedano Berta,Pastor Pau,Errazquin Francisco Perez,PeriɁȥn‐Tocino Teresa,Ruiz‐Martȷnez Javier,Ruz Clara,Rodriguez Antonio Sanchez,Sierra Marȷa,Suarez‐Sanmartin Esther,Tabernero Cesar,Tartari Juan Pablo,Tejera‐Parrado Cristina,Tolosa Eduard,Valldeoriola Francesc,Vargas‐Gonzȥlez Laura,Vela Lydia,Vives Francisco,Zimprich Alexander,Pihlstrom Lasse,Toft Mathias,Koks Sulev,Taba Pille,Hassin‐Baer Sharon,Cookson Mark R.4,Nalls Mike A.111,Singleton Andrew B.1,

Affiliation:

1. Molecular Genetics Section, Laboratory of Neurogenetics National Institute on Aging, National Institutes of Health Bethesda Maryland USA

2. Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA) Granada Spain

3. Transgenics Section, Laboratory of Neurogenetics National Institute on Aging, National Institutes of Health Bethesda Maryland USA

4. Cell Biology and Gene Expression Section, Laboratory of Neurogenetics National Institute on Aging, National Institutes of Health Bethesda Maryland USA

5. Department of Molecular and Clinical Pharmacology Institute of Translational Medicine, University of Liverpool Liverpool United Kingdom

6. Department of Pathophysiology University of Tartu Tartu Estonia

7. Computational Biology Group, Laboratory of Neurogenetics National Institute on Aging, National Institutes of Health Bethesda Maryland USA

8. Department of Neurology Oslo University Hospital Oslo Norway

9. Department of Neurology and Neurosurgery, Department of Human Genetics McGill University Montréal, Quebec Canada

10. Department of Neurology and Neurosurgery Montreal Neurological Institute, McGill University Montréal, Quebec Canada

11. Data Tecnica International Glen Echo Maryland USA

Funder

National Institutes of Health

U.S. Department of Defense

Publisher

Wiley

Subject

Neurology (clinical),Neurology

Reference53 articles.

1. Selective neuronal vulnerability in Parkinson disease

2. Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance

3. Genetic risk factors in Parkinson’s disease

4. Parkinson's disease genetics: identifying novel risk loci, providing causal insights and improving estimates of heritable risk;Nalls MA;bioRxiv,2018

5. GCTA: A Tool for Genome-wide Complex Trait Analysis

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