Programmed −1 ribosomal frameshifting in the SARS coronavirus-Reference-Cited by-同舟云学术

Programmed −1 ribosomal frameshifting in the SARS coronavirus

Published:2004-10-26 Issue:6 Volume:32 Page:1081-1083
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Ramos F. Dos¹,Carrasco M.¹,Doyle T.²,Brierley I.²

Affiliation:

1. Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Box 157, Cambridge CB2 2QQ, U.K.

2. Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, U.K.

Abstract

Programmed −1 ribosomal frameshifting is an alternate mechanism of translation used by coronavirus to synthesize replication proteins encoded by two overlapping open reading frames. For some coronaviruses, the mRNA cis-acting stimulatory structures involved in this process have been characterized, but their precise contribution to ribosomal frameshifting is not completely understood. Recently, a novel coronavirus was identified as the causative agent of the severe acute respiratory syndrome. This review describes the mRNA motifs involved in programmed −1 ribosomal frameshifting in this virus.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/32/6/1081/512435/bst0321081.pdf

Reference15 articles.

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