Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome

Author:

Rota Paul A.1234,Oberste M. Steven1234,Monroe Stephan S.1234,Nix W. Allan1234,Campagnoli Ray1234,Icenogle Joseph P.1234,Peñaranda Silvia1234,Bankamp Bettina1234,Maher Kaija1234,Chen Min-hsin1234,Tong Suxiong1234,Tamin Azaibi1234,Lowe Luis1234,Frace Michael1234,DeRisi Joseph L.1234,Chen Qi1234,Wang David1234,Erdman Dean D.1234,Peret Teresa C. T.1234,Burns Cara1234,Ksiazek Thomas G.1234,Rollin Pierre E.1234,Sanchez Anthony1234,Liffick Stephanie1234,Holloway Brian1234,Limor Josef1234,McCaustland Karen1234,Olsen-Rasmussen Melissa1234,Fouchier Ron1234,Günther Stephan1234,Osterhaus Albert D. M. E.1234,Drosten Christian1234,Pallansch Mark A.1234,Anderson Larry J.1234,Bellini William J.1234

Affiliation:

1. National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.

2. Departments of Biochemistry and Biophysics, University of California–San Francisco, San Francisco, CA 94143, USA.

3. Department of Virology, Erasmus University, Rotterdam, 3000 DR, Netherlands.

4. Department of Virology, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany.

Abstract

In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratorysyndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closelyrelated to anyof the previouslycharacterized coronaviruses.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference31 articles.

1. S. M. Poutanen et al. N. Engl. J. Med. available 17 April 2003 at http://nejm.org/earlyrelease/sars.asp#4-2.

2. N. Lee et al. N. Engl. J. Med. available 17 April 2003 at http://nejm.org/earlyrelease/sars.asp#4-2.

3. K. W. Tsang et al. N. Engl. J. Med. available 17 April 2003 at http://nejm.org/earlyrelease/sars.asp#4-2.

4. Centers for Disease Control and Prevention, Morb. Mortal. Wkly. Rep.52, 357 (2003).

5. Managing SARS amidst Uncertainty

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