The Genome Sequence of the SARS-Associated Coronavirus
Author:
Marra Marco A.1234, Jones Steven J. M.1234, Astell Caroline R.1234, Holt Robert A.1234, Brooks-Wilson Angela1234, Butterfield Yaron S. N.1234, Khattra Jaswinder1234, Asano Jennifer K.1234, Barber Sarah A.1234, Chan Susanna Y.1234, Cloutier Alison1234, Coughlin Shaun M.1234, Freeman Doug1234, Girn Noreen1234, Griffith Obi L.1234, Leach Stephen R.1234, Mayo Michael1234, McDonald Helen1234, Montgomery Stephen B.1234, Pandoh Pawan K.1234, Petrescu Anca S.1234, Robertson A. Gordon1234, Schein Jacqueline E.1234, Siddiqui Asim1234, Smailus Duane E.1234, Stott Jeff M.1234, Yang George S.1234, Plummer Francis1234, Andonov Anton1234, Artsob Harvey1234, Bastien Nathalie1234, Bernard Kathy1234, Booth Timothy F.1234, Bowness Donnie1234, Czub Martin1234, Drebot Michael1234, Fernando Lisa1234, Flick Ramon1234, Garbutt Michael1234, Gray Michael1234, Grolla Allen1234, Jones Steven1234, Feldmann Heinz1234, Meyers Adrienne1234, Kabani Amin1234, Li Yan1234, Normand Susan1234, Stroher Ute1234, Tipples Graham A.1234, Tyler Shaun1234, Vogrig Robert1234, Ward Diane1234, Watson Brynn1234, Brunham Robert C.1234, Krajden Mel1234, Petric Martin1234, Skowronski Danuta M.1234, Upton Chris1234, Roper Rachel L.1234
Affiliation:
1. British Columbia Cancer Agency (BCCA) Genome Sciences Centre, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada. 2. National Microbiology Laboratory, 1015 Arlington Street, Winnipeg, Manitoba R3E 3R2, Canada. 3. British Columbia Centre for Disease Control and University of British Columbia Centre for Disease Control, 655 West 12th Avenue, Vancouver, British Columbia V5Z 4R4, Canada. 4. Department of Biochemistry and Microbiology, University of Victoria, Post Office Box 3055 STN CSC, Victoria, British Columbia V8W 3P6, Canada.
Abstract
We sequenced the 29,751-base genome of the severe acute respiratory syndrome (SARS)âassociated coronavirus known as the Tor2 isolate. The genome sequence reveals that this coronavirus is only moderately related to other known coronaviruses, including two human coronaviruses, HCoV-OC43 and HCoV-229E. Phylogenetic analysis of the predicted viral proteins indicates that the virus does not closely resemble any of the three previously known groups of coronaviruses. The genome sequence will aid in the diagnosis of SARS virus infection in humans and potential animal hosts (using polymerase chain reaction and immunological tests), in the development of antivirals (including neutralizing antibodies), and in the identification of putative epitopes for vaccine development.
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Reference35 articles.
1. C. A. Donnelly et al. Lancet ; published online 7 May 2003 (http://image.thelancet.com/extras/03art4453web.pdf). 2. J. S. M. Peiris et al . Lancet ; published online 8 April 2003 (http://image.thelancet.com/extras/03art3477web.pdf). 3. N. Engl. J. Med. 2003 4. Robert Koch 5. Fields Virology 2001
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