Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as Factor Xa Inhibitors IV. A Series of New Derivatives Containing a Spiro[5H-oxazolo[3,2-a]pyrazine-2(3H),4'-piperidin]-5-one Skeleton-Reference-Cited by-同舟云学术

Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as Factor Xa Inhibitors IV. A Series of New Derivatives Containing a Spiro[5H-oxazolo[3,2-a]pyrazine-2(3H),4'-piperidin]-5-one Skeleton

Published:2004 Issue:4 Volume:52 Page:406-412
ISSN:0009-2363
Container-title:Chemical and Pharmaceutical Bulletin
language:en
Short-container-title:CHEMICAL & PHARMACEUTICAL BULLETIN

Author:

Nishida Hidemitsu¹,Mukaihira Takafumi¹,Saitoh Fumihiko¹,Harada Kousuke¹,Fukui Miyuki¹,Matsusue Tomokazu¹,Okamoto Atsushi¹,Hosaka Yoshitaka¹,Matsumoto Miwa¹,Shiromizu Ikuya¹,Ohnishi Shuhei¹,Mochizuki Hidenori¹

Affiliation:

1. Discovery Research Center, Mochida Pharmaceutical Co., Ltd.

Publisher

Pharmaceutical Society of Japan

Subject

Drug Discovery,General Chemistry,General Medicine

Link

http://www.jstage.jst.go.jp/article/cpb/52/4/52_4_406/_pdf

Reference32 articles.

1. Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as Factor Xa Inhibitor.

2. Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as a Factor Xa Inhibitor. II. Substituent Effect on Biological Activities.

3. Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as Factor Xa Inhibitors III. Effect of Ring Opening of Piperazinone Moiety on Inhibition