1. Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as Factor Xa Inhibitor.
2. 2) This work was partially presented at the XVIth International Symposium on Medicinal Chemistry in Bologna, Italy, September 18—22, 2000, Program No. PA-125: Nishida H., Miyazaki Y., Mukaihira T., Saitoh F., Harada K., Shimada H., Mizuno M., Matsusue T., Okamoto A., Hosaka Y., Matumoto M., Kamiya M., Kurokawa M., Mizuguchi K., Ohnishi S., Mochizuki H., Synthesis and biological activities of the 2-piperazinone derivative (M55190), an orally active and highly specific factor Xa inhibitor.
3. The coagulation cascade: initiation, maintenance, and regulation
4. Activation of human prothrombin by highly purified human factors V and X-a in presence of human antithrombin.
5. Surface-dependent reactions of the vitamin K-dependent enzyme complexes