What does the aromatic ring number mean for drug design?
Author:
Affiliation:
1. University of Sussex, Translational Drug Discovery Group, Brighton, East Sussex, BN1 9QJ, UK ;
2. University of Sussex, Translational Drug Discovery Group, Brighton, East Sussex, BN1 9QJ, UK
Publisher
Informa Healthcare
Subject
Drug Discovery
Link
https://www.tandfonline.com/doi/pdf/10.1517/17460441.2014.932346
Reference32 articles.
1. The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?
2. The impact of aromatic ring count on compound developability: further insights by examining carbo- and hetero-aromatic and -aliphatic ring types
3. The developability of heteroaromatic and heteroaliphatic rings – do some have a better pedigree as potential drug molecules than others?
4. Improving Drug Candidates by Design: A Focus on Physicochemical Properties As a Means of Improving Compound Disposition and Safety
5. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
Cited by 59 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Rhodium-catalyzed enantioselective in situ C(sp3)−H heteroarylation by a desymmetrization approach;Chinese Chemical Letters;2024-10
2. A potent therapeutic scaffold fusing quinazolinone/melatonin for future colorectal cancer interventions: design, one-pot synthesis, biological and ADME-tox modeling studies;Medicinal Chemistry Research;2024-09-02
3. An efficient approach to produce flavonoid monophosphate by a coupled bienzymatic system;Chemical Engineering Journal;2024-09
4. Synthesis, structural characterization and antitrypanosomal activity of ferrocenyl-based imines with (2 or 4)-nitrophenyl-2-furan group;Inorganic Chemistry Communications;2024-09
5. SmartCADD: AI-QM Empowered Drug Discovery Platform with Explainability;Journal of Chemical Information and Modeling;2024-08-23
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3