What does the aromatic ring number mean for drug design?
Author:
Affiliation:
1. University of Sussex, Translational Drug Discovery Group, Brighton, East Sussex, BN1 9QJ, UK ;
2. University of Sussex, Translational Drug Discovery Group, Brighton, East Sussex, BN1 9QJ, UK
Publisher
Informa Healthcare
Subject
Drug Discovery
Link
https://www.tandfonline.com/doi/pdf/10.1517/17460441.2014.932346
Reference32 articles.
1. The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?
2. The impact of aromatic ring count on compound developability: further insights by examining carbo- and hetero-aromatic and -aliphatic ring types
3. The developability of heteroaromatic and heteroaliphatic rings – do some have a better pedigree as potential drug molecules than others?
4. Improving Drug Candidates by Design: A Focus on Physicochemical Properties As a Means of Improving Compound Disposition and Safety
5. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
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