The developability of heteroaromatic and heteroaliphatic rings – do some have a better pedigree as potential drug molecules than others?-Reference-Cited by-同舟云学术

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The developability of heteroaromatic and heteroaliphatic rings – do some have a better pedigree as potential drug molecules than others?

Published:2012 Issue:9 Volume:3 Page:1062
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Ritchie Timothy J.,Macdonald Simon J. F.,Peace Simon,Pickett Stephen D.,Luscombe Christopher N.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2012/MD/C2MD20111A

Reference25 articles.

1. The productivity crisis in pharmaceutical R&D

2. Improving Drug Candidates by Design: A Focus on Physicochemical Properties As a Means of Improving Compound Disposition and Safety

3. The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?

4. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

5. Impact of ion class and time on oral drug molecular properties

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