Replacing the phthalimide core in thalidomide with benzotriazole-Reference-Cited by-同舟云学术

Replacing the phthalimide core in thalidomide with benzotriazole

Published:2022-02-28 Issue:1 Volume:37 Page:527-530
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Krasavin Mikhail¹^ORCID,Bubyrev Andrey¹,Kazantsev Alexander¹,Heim Christopher²,Maiwald Samuel²,Zhukovsky Daniil¹,Dar’in Dmitry¹,Hartmann Marcus D.²^ORCID,Bunev Alexander³

Affiliation:

1. Institute of Chemistry, Saint Petersburg State University, Saint Petersburg, Russia

2. Department of Protein Evolution, Max Planck Institute for Developmental Biology, Tübingen, Germany

3. Medicinal Chemistry Center, Togliatti State University, Togliatti, Russia

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2021.2024525

Reference20 articles.

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3. Identification of probe-quality degraders for Poly(ADP-ribose) polymerase-1 (PARP-1)

4. A MedChem toolbox for cereblon-directed PROTACs

5. A MedChem toolbox for cereblon-directed PROTACs

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1. Discovery and characterization of potent spiro-isoxazole-based cereblon ligands with a novel binding mode;European Journal of Medicinal Chemistry;2024-04

2. N-Boc-α-diazo glutarimide as efficient reagent for assembling N-heterocycle-glutarimide diads via Rh(II)-catalyzed N–H insertion reaction;Beilstein Journal of Organic Chemistry;2023-12-07

3. PROTACs Targeting MLKL Protect Cells from Necroptosis;Journal of Medicinal Chemistry;2023-08-03

4. Cereblon neo-substrate binding mimics the recognition of the cyclic imide degron;Biochemical and Biophysical Research Communications;2023-02

5. Synthesis of novel glutarimide derivatives via the Michael addition of (hetero)aromatic thiols: pronounced effect of sulfur oxidation on cytotoxicity towards multiple myeloma cell lines;Mendeleev Communications;2023-01