Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation-Reference-Cited by-同舟云学术

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Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation

Published:2020-09 Issue: Volume:201 Page:112451
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Donoghue Craig,Cubillos-Rojas Monica,Gutierrez-Prat Nuria,Sanchez-Zarzalejo Carolina,Verdaguer Xavier,Riera Antoni,Nebreda Angel R.

Funder

Agència de Gestió d'Ajuts Universitaris i de Recerca

Ministerio de Ciencia e Innovación

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference32 articles.

1. Mechanisms and functions of p38 MAPK signalling;Cuadrado;Biochem. J.,2010

2. Genetic analysis of specific and redundant roles for p38alpha and p38beta MAPKs during mouse development;del Barco Barrantes;Proc. Natl. Acad. Sci. U. S. A.,2011

3. SnapShot: p38 MAPK substrates;Trempolec;Cell,2013

4. Successful structure-based design of recent p38 MAP kinase inhibitors;Karcher;Curr. Top. Med. Chem.,2009

5. p38 mitogen-activated protein kinase-independent induction of gadd45 expression in nerve growth factor-induced apoptosis in medulloblastomas;Chou;J. Biol. Chem.,2001

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3. Application and challenges of nitrogen heterocycles in PROTAC linker;European Journal of Medicinal Chemistry;2024-07

4. Nanoparticle-mediated delivery of peptide-based degraders enables targeted protein degradation;2024-05-22

5. Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors;Journal of Medicinal Chemistry;2024-04-24

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