Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and accessibility of their bioactive conformation on VEGFR-2 activities

Author:

Jaballah Maiy Y.1,Serya Rabah A. T.1,Saad Nasser2,Khojah Sohair M.3,Ahmed Marawan4,Barakat Khaled456,Abouzid Khaled A. M.17

Affiliation:

1. Faculty of Pharmacy, Pharmaceutical Chemistry Department, Ain Shams University, Abbassia, Cairo, Egypt;

2. Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Pharmaceutical Chemistry Department, Future University in Egypt, Cairo, Egypt;

3. Faculty of Science, Biochemistry Department, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia;

4. Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada;

5. Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, Canada;

6. Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, AB, Canada;

7. Faculty of Pharmacy, Department of Organic and Medicinal Chemistry, University of Sadat City, Menoufia, Egypt

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

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