Signal transduction by vascular endothelial growth factor receptors-Reference-Cited by-同舟云学术

Signal transduction by vascular endothelial growth factor receptors

Published:2011-06-28 Issue:2 Volume:437 Page:169-183
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Koch Sina¹,Tugues Sònia¹,Li Xiujuan¹,Gualandi Laura¹,Claesson-Welsh Lena¹

Affiliation:

1. Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Dag Hammarskjöldsv. 20, 751 85 Uppsala, Sweden

Abstract

VEGFs (vascular endothelial growth factors) control vascular development during embryogenesis and the function of blood vessels and lymphatic vessels in the adult. There are five related mammalian ligands, which act through three receptor tyrosine kinases. Signalling is modulated through neuropilins, which act as VEGF co-receptors. Heparan sulfate and integrins are also important modulators of VEGF signalling. Therapeutic agents that interfere with VEGF signalling have been developed with the aim of decreasing angiogenesis in diseases that involve tissue growth and inflammation, such as cancer. The present review will outline the current understanding and consequent biology of VEGF receptor signalling.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/437/2/169/668599/bj4370169.pdf

Reference265 articles.

1. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid;Senger;Science,1983

2. Purification and characterization of a naturally occurring vascular endothelial growth factor·placenta growth factor heterodimer;DiSalvo;J. Biol. Chem.,1995

3. Binding to the extracellular matrix and proteolytic processing: two key mechanisms regulating vascular endothelial growth factor action;Ferrara;Mol. Biol. Cell,2010

4. Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors;Lee;J. Cell Biol.,2005

5. Structure–function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling;Grunewald;Biochim. Biophys. Acta,2010

Cited by 698 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Natural products‐based antiangiogenic agents: New frontiers in cancer therapy;Food Frontiers;2024-09

2. Perspective Chapter: Translational implications of Proliferative Diabetic Retinopathy (PDR) vitreous fluid;Diabetic Retinopathy - Advancement in Understanding the Pathophysiology and Management Strategies [Working Title];2024-08-29

3. Enhanced anti-angiogenic effects of aprepitant-loaded nanoparticles in human umbilical vein endothelial cells;Scientific Reports;2024-08-27

4. Enhancing therapeutic potential: Human adipose‐derived mesenchymal stem cells modified with recombinant adeno‐associated virus expressing VEGF165 gene for peripheral nerve injury;The Kaohsiung Journal of Medical Sciences;2024-08-05

5. Triple negative breast cancer cells exposed to aryl hydrocarbon receptor ligands hexachlorobenzene and chlorpyrifos activate endothelial cells;Chemico-Biological Interactions;2024-08