Design and synthesis of novel chloropyridazine hybrids as promising anticancer agents acting by apoptosis induction and PARP-1 inhibition through a molecular hybridization strategy-Reference-Cited by-同舟云学术

Design and synthesis of novel chloropyridazine hybrids as promising anticancer agents acting by apoptosis induction and PARP-1 inhibition through a molecular hybridization strategy

Published:2024 Issue:3 Volume:15 Page:981-997
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Abdelrahman Norhan A.¹,Al-Karmalawy Ahmed A.²³^ORCID,Jaballah Maiy Y.¹,Yahya Galal⁴⁵,Sharaky Marwa⁶⁷,Abouzid Khaled A. M.¹^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain-Shams University, Cairo 11566, Egypt

2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta 34518, Egypt

3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza 12566, Egypt

4. Department of Microbiology and Immunology, Zagazig University, Zagazig 44519, Egypt

5. Molecular Biology Institute of Barcelona, Spanish National Research Council, Catalonia, Spain

6. Cancer Biology Department, Pharmacology Unit, National Cancer Institute (NCI), Cairo University, Cairo, Egypt

7. Biochemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza 12566, Egypt

Abstract

Novel chloropyridazine hybrids as promising anticancer agents acting by apoptosis induction and PARP-1 inhibition through a molecular hybridization strategy.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00751K

Reference62 articles.

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