Using hydrogen peroxide to prevent antibody disulfide bond reduction during manufacturing process-Reference-Cited by-同舟云学术

Using hydrogen peroxide to prevent antibody disulfide bond reduction during manufacturing process

Published:2018-01-23 Issue:3 Volume:10 Page:500-510
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Du Cheng¹^ORCID,Huang Yunping²,Borwankar Ameya¹,Tan Zhijun¹,Cura Anthony¹,Yee Joon Chong¹,Singh Nripen¹,Ludwig Richard²,Borys Michael¹,Ghose Sanchayita¹,Mussa Nesredin¹,Li Zheng Jian¹

Affiliation:

1. Biologics Process Development, Bristol-Myers Squibb Company, Devens, MA, USA

2. Molecular and Analytical Development, Bristol-Myers Squibb Company, Pennington, NJ, USA

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2018.1424609

Reference31 articles.

1. Air sparging for prevention of antibody disulfide bond reduction in harvested CHO cell culture fluid

2. Antibody disulfide bond reduction during process development: Insights using a scale-down model process

3. Disulphide bond reduction of a therapeutic monoclonal antibody during cell culture manufacturing operations

4. Mechanism of antibody reduction in cell culture production processes

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