Disulphide bond reduction of a therapeutic monoclonal antibody during cell culture manufacturing operations-Reference-Cited by-同舟云学术

Disulphide bond reduction of a therapeutic monoclonal antibody during cell culture manufacturing operations

Published:2011-11-22 Issue:S8 Volume:5 Page:
ISSN:1753-6561
Container-title:BMC Proceedings
language:en
Short-container-title:BMC Proc

Author:

Mullan Brian,Dravis Bryan,Lim Amareth,Clarke Ambrose,Janes Susan,Lambooy Pete,Olson Don,O’Riordan Tomas,Ricart Bruce,Tulloch Alexander G

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://link.springer.com/content/pdf/10.1186/1753-6561-5-S8-P110.pdf

Reference7 articles.

1. Wypych J, et al: Human IgG2 antibodies display disulfide-mediated structural isoforms. J Biol Chem. 2008, 283: 16194-16205. 10.1074/jbc.M709987200.

2. Liu YD, et al: Human IgG2 antibody disulfide rearrangement in vivo. J Biol Chem. 2008, 283: 29266-29272. 10.1074/jbc.M804787200.

3. van der Neut Kolfschoten M: Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange. Science. 2007, 317: 1554-1557. 10.1126/science.1144603.

4. Labrijn AF, et al: Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo. Nature Biotechnology. 2009, 27: 767-773. 10.1038/nbt.1553.

5. Trexler-Schmidt M, et al: Identification and Prevention of Antibody Disulfide Bond Reduction During Cell Culture Manufacturing. Biotechnology and Bioengineering. 2010, 106: 452- 461.

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