Antibody disulfide bond reduction during process development: Insights using a scale-down model process-Reference-Cited by-同舟云学术

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Antibody disulfide bond reduction during process development: Insights using a scale-down model process

Published:2015-12 Issue:S9 Volume:9 Page:
ISSN:1753-6561
Container-title:BMC Proceedings
language:en
Short-container-title:BMC Proc

Author:

Ruaudel Julie,Bertschinger Martin,Letestu Sonia,Giovannini Roberto,Wassmann Paul,Moretti Pierre

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://link.springer.com/content/pdf/10.1186/1753-6561-9-S9-P24.pdf

Reference4 articles.

1. Melody Trexler-Schmidt, Sandy Sargis, Jason Chiu, Stefanie Sze-Khoo, Melissa Mun, Yung-Hsiang Kao, Michael Laird: Identification and Prevention of Antibody Disulfide Bond Reduction During Cell Culture Manufacturing. Biotechnology and Bioengineering. 2010, 106 (3):

2. Hongcheng Liu, Georgeen Gaza-Bulseco, Chris Chumsae, Abigail Newby-Kew: Characterization of lower molecular weight artefact bands of recombinant monoclonal IgG1 antibodies on non-reducing SDS-PAGE. Biotechnol Lett. 2007, 29: 1611-1622.

3. Hutterer KM, Hong RW, Lull J, Zhao X, Wang T, Pei R, Le ME, Borisov O, Piper R, Liu YD, Petty K, Apostol I, Flynn GC: Monoclonal antibody disulfide reduction during manufacturing: Untangling process effects from product effects. MAbs. 2013, 5 (4): 608-13. Jul-Aug;. doi: 10.4161/mabs.24725. Epub 2013 Apr 18

4. Wendy Chaderjian, Edward Chin, Reed Harris, Tina Etcheverry: Effect of copper sulfate on performance of a serum-free CHO cell culture process and the level of free thiol in the recombinant antibody expressed. Biotechnol Prog. 2005, 21: 550-553.

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Development and application of an analytical approach to assess an antibody's potential for disulfide reduction;Biotechnology Progress;2022-01-09

2. Determination of free sulfhydryl contents for proteins including monoclonal antibodies by use of SoloVPE;Journal of Pharmaceutical and Biomedical Analysis;2021-07

3. Impact of depth filtration on disulfide bond reduction during downstream processing of monoclonal antibodies from CHO cell cultures;Biotechnology and Bioengineering;2019-04-04

4. Direct mass spectrometric characterization of disulfide linkages;mAbs;2018-03-14

5. Using hydrogen peroxide to prevent antibody disulfide bond reduction during manufacturing process;mAbs;2018-01-23

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