Abstract
SARS-CoV-2 produces two long viral protein precursors from one open reading frame using a highly conserved RNA pseudoknot that enhances programmed −1 ribosomal frameshifting. The 1.3 Å-resolution X-ray structure of the pseudoknot reveals three coaxially stacked helices buttressed by idiosyncratic base triples from loop residues. This structure represents a frameshift-stimulating state that must be deformed by the ribosome and exhibits base-triple-adjacent pockets that could be targeted by future small-molecule therapeutics.
Funder
National Institute of General Medical Sciences of the National Institutes of Health
NIH-ORIP HEI
National Heart, Lung, and Blood Institute
NIH Intramural Targeted Anti-COVID-19 (ITAC) Program of the National Institute of Allergy and Infectious Diseases and the intramural program of the NHLBI, NIH
Publisher
Cold Spring Harbor Laboratory
Cited by
33 articles.
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