Antiproliferative effect, cell cycle arrest and apoptosis generation of novel 6-substituted N5-formyltetrahydropyrido[3,2-d]pyrimidine derivatives-Reference-Cited by-同舟云学术

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Antiproliferative effect, cell cycle arrest and apoptosis generation of novel 6-substituted N5-formyltetrahydropyrido[3,2-d]pyrimidine derivatives

Published:2023-06-01 Issue:8 Volume:32 Page:1666-1676
ISSN:1054-2523
Container-title:Medicinal Chemistry Research
language:en
Short-container-title:Med Chem Res

Author:

Gao Chonghui,Yuan Mengmeng,Jiang Wei,Wang Rongrong,Zheng Baoyan,Liu Junyi,Zhang Zhili,Tian Chao,Wang Meng

Funder

Beihua University Postgraduate Innovation Project

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics

Link

https://link.springer.com/content/pdf/10.1007/s00044-023-03082-2.pdf

Reference30 articles.

1. Kordus SL, Baughn AD. Revitalizing antifolates through understanding mechanisms that govern susceptibility and resistance. Med Chem Comm. 2019;10:880–95. https://doi.org/10.1039/c9md00078j.

2. Tian C, Wang M, Han Z, Fang F, Zhang Z, Wang X, et al. Design, synthesis and biological evaluation of novel 6-substituted pyrrolo [3, 2-d] pyrimidine analogues as antifolate antitumor agents. Eur J Med Chem. 2017;138:630–43. https://doi.org/10.1016/j.ejmech.2017.07.002.

3. Abdelaziz OA, El Husseiny WM, Selim KB, Eisa HM. Dihydrofolate reductase inhibition effect of 5-substituted pyrido[2, 3-d]pyrimidines: Synthesis, antitumor activity and molecular modeling study. Bioorg Chem. 2019;90:103076. https://doi.org/10.1016/j.bioorg.2019.103076.

4. Gao T, Zhang C, Shi X, Guo R, Zhang K, Gu J, et al. Targeting dihydrofolate reductase: Design, synthesis and biological evaluation of novel 6-substituted pyrrolo[2, 3-d]pyrimidines as nonclassical antifolates and as potential antitumor agents. Eur J Med Chem. 2019;178:329–40. https://doi.org/10.1016/j.ejmech.2019.06.013.

5. Wang M, Yang J, Yuan M, Xue L, Li H, Tian C, et al. Synthesis and antiproliferative activity of a series of novel 6-substituted pyrido[3, 2-d]pyrimidines as potential nonclassical lipophilic antifolates targeting dihydrofolate reductase. Eur J Med Chem. 2017;128:88–97. https://doi.org/10.1016/j.ejmech.2017.01.033.

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