Design, synthesis and biological evaluation of novel 6-substituted pyrrolo [3,2- d ] pyrimidine analogues as antifolate antitumor agents-Reference-Cited by-同舟云学术

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Design, synthesis and biological evaluation of novel 6-substituted pyrrolo [3,2- d ] pyrimidine analogues as antifolate antitumor agents

Published:2017-09 Issue: Volume:138 Page:630-643
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Tian Chao,Wang Meng,Han Zifei,Fang Fang,Zhang Zhili,Wang Xiaowei,Liu Junyi

Funder

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference36 articles.

1. The antifolates;Visentin;Hematol. Oncol. Clin. North Am.,2012

2. Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance;Gonen;Drug resist. Updat.,2012

3. Structure, dynamics and catalytic function of dihydrofolate reductase;Schnell;Annu. Rev. Biophys. Biomol. Struct.,2004

4. Structure-guided discovery of thiazolidine-2,4-dione derivatives as a novel class of leishmania major pteridine reductase 1 inhibitors;Leite;Eur. J. Med. Chem.,2016

5. Folates in pyrimidine nucleotide biosynthesis;Santi,1984

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2. Synthesis and dihydrofolate reductase inhibitory activity of 2-amino-6-(arylaminomethyl) thieno[2,3-d]pyrimidin-4(3H)-ones;Chemija;2023-09-17

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4. Antiproliferative effect, cell cycle arrest and apoptosis generation of novel 6-substituted N5-formyltetrahydropyrido[3,2-d]pyrimidine derivatives;Medicinal Chemistry Research;2023-06-01

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