Novel Glu-based pyrazolo[3,4-d]pyrimidine analogues: design, synthesis and biological evaluation as DHFR and TS dual inhibitors-Reference-Cited by-同舟云学术

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Novel Glu-based pyrazolo[3,4-d]pyrimidine analogues: design, synthesis and biological evaluation as DHFR and TS dual inhibitors

Published:2023-04-20 Issue:1 Volume:38 Page:
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Mahnashi Mater¹,Alshahrani Mohammed Merae²,Al Ali Amer³,Asiri Abdulaziz³,Abou-Salim Mahrous A.⁴

Affiliation:

1. Department of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran, Saudi Arabia

2. Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, Najran, Saudi Arabia

3. Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, University of Bisha, Bisha, Saudi Arabia

4. Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt

Funder

Najran University

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2023.2203879

Reference73 articles.

1. DNA replication and cancer: From dysfunctional replication origin activities to therapeutic opportunities

2. DHFR Inhibitors: Reading the Past for Discovering Novel Anticancer Agents

3. Design, synthesis and biological evaluation of novel 6-substituted pyrrolo [3,2- d ] pyrimidine analogues as antifolate antitumor agents

4. Enhancement of the brain delivery of methotrexate with administration of mid-chain ester prodrugs: In vitro and in vivo studies

5. Recent Advances in Classical and Non-Classical Antifolates as Antitumor and Antiopportunistic Infection Agents: Part I

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4. A novel strategy to bind pyrimidine sulfonamide derivatives with odd even chains: exploration of their design, synthesis and biological activity evaluation;Molecular Diversity;2023-12-12

5. Synthesis and dihydrofolate reductase inhibitory activity of 2-amino-6-(arylaminomethyl) thieno[2,3-d]pyrimidin-4(3H)-ones;Chemija;2023-09-17

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