Toxicology of 3-monochloropropane-1,2-diol and its esters: a narrative review
Author:
Funder
Ministero della Salute
Publisher
Springer Science and Business Media LLC
Subject
Health, Toxicology and Mutagenesis,Toxicology,General Medicine
Link
https://link.springer.com/content/pdf/10.1007/s00204-023-03467-7.pdf
Reference94 articles.
1. Aasa J, Abramsson-Zetterberg L, Carlsson H, Törnqvist M (2017a) The genotoxic potency of glycidol established from micronucleus frequency and hemoglobin adduct levels in mice. Food Chem Toxicol 100:168–174. https://doi.org/10.1016/j.fct.2016.12.022
2. Aasa J, Törnqvist M, Abramsson-Zetterberg L (2017b) Measurement of micronuclei and internal dose in mice demonstrates that 3-monochloropropane-1,2-diol (3-MCPD) has no genotoxic potency in vivo. Food Chem Toxicol 109:414–420. https://doi.org/10.1016/j.fct.2017.09.019
3. Abraham K, Appel KE, Berger-Preiss E et al (2013) Relative oral bioavailability of 3-MCPD from 3-MCPD fatty acid esters in rats. Arch Toxicol 87:649–659. https://doi.org/10.1007/s00204-012-0970-8
4. Abraham K, Hielscher J, Kuhlmann J, Monien BH (2021) Urinary excretion of 2/3-monochloropropanediol (2/3-MCPD) and 2,3-dihydroxypropylmercapturic acid (DHPMA) after a single high dose of fatty acid esters of 2/3-MCPD and glycidol: a controlled exposure study in humans. Mol Nutr Food Res 65:e2000735. https://doi.org/10.1002/mnfr.202000735
5. Andreoli R, Cirlini M, Mutti A (2015) Quantification of 3-MCPD and its mercapturic metabolite in human urine: validation of an LC-MS-MS method and its application in the general population. Anal Bioanal Chem 407:4823–4827. https://doi.org/10.1007/s00216-015-8650-1
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