Allelic Expression Imbalance: Tipping the Scales to Elucidate the Function of Type 2 Diabetes

Allelic Expression Imbalance: Tipping the Scales to Elucidate the Function of Type 2 Diabetes–Associated Loci

Published:2015-03-17 Issue:4 Volume:64 Page:1102-1104
ISSN:0012-1797
Container-title:Diabetes
language:en
Short-container-title:

Author:

McCormack Shana E.¹²,Grant Struan F.A.¹²³

Affiliation:

1. Division of Endocrinology and Diabetes, Children’s Hospital of Philadelphia, Philadelphia, PA

2. Department of Pediatrics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

3. Division of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, PA

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://journals.org/diabetes/diabetes/article-pdf/64/4/1102/579555/db141836.pdf

Reference15 articles.

1. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility;Mahajan;Nat Genet,2014

2. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity;Frayling;Science,2007

3. A genome-wide association meta-analysis identifies new childhood obesity loci;Bradfield;Nat Genet,2012

4. Obesity-associated variants within FTO form long-range functional connections with IRX3;Smemo;Nature,2014

5. Targeted allelic expression profiling in human islets identifies cis-regulatory effects for multiple variants identified by type 2 diabetes genome-wide association studies;Locke;Diabetes,2015

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1. AIJ: joint test for simultaneous detection of imprinting and non-imprinting allelic expression imbalance;Mathematical Biosciences and Engineering;2020

2. Exome sequencing-based identification of novel type 2 diabetes risk allele loci in the Qatari population;PLOS ONE;2018-09-13

3. DNA methylation signatures of educational attainment;npj Science of Learning;2018-03-23