A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity-Reference-Cited by-同舟云学术

A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

Published:2007-05-11 Issue:5826 Volume:316 Page:889-894
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Frayling Timothy M.¹²³⁴⁵,Timpson Nicholas J.¹²³⁴⁵,Weedon Michael N.¹²³⁴⁵,Zeggini Eleftheria¹²³⁴⁵,Freathy Rachel M.¹²³⁴⁵,Lindgren Cecilia M.¹²³⁴⁵,Perry John R. B.¹²³⁴⁵,Elliott Katherine S.¹²³⁴⁵,Lango Hana¹²³⁴⁵,Rayner Nigel W.¹²³⁴⁵,Shields Beverley¹²³⁴⁵,Harries Lorna W.¹²³⁴⁵,Barrett Jeffrey C.¹²³⁴⁵,Ellard Sian¹²³⁴⁵,Groves Christopher J.¹²³⁴⁵,Knight Bridget¹²³⁴⁵,Patch Ann-Marie¹²³⁴⁵,Ness Andrew R.¹²³⁴⁵,Ebrahim Shah¹²³⁴⁵,Lawlor Debbie A.¹²³⁴⁵,Ring Susan M.¹²³⁴⁵,Ben-Shlomo Yoav¹²³⁴⁵,Jarvelin Marjo-Riitta¹²³⁴⁵,Sovio Ulla¹²³⁴⁵,Bennett Amanda J.¹²³⁴⁵,Melzer David¹²³⁴⁵,Ferrucci Luigi¹²³⁴⁵,Loos Ruth J. F.¹²³⁴⁵,Barroso IneÌs¹²³⁴⁵,Wareham Nicholas J.¹²³⁴⁵,Karpe Fredrik¹²³⁴⁵,Owen Katharine R.¹²³⁴⁵,Cardon Lon R.¹²³⁴⁵,Walker Mark¹²³⁴⁵,Hitman Graham A.¹²³⁴⁵,Palmer Colin N. A.¹²³⁴⁵,Doney Alex S. F.¹²³⁴⁵,Morris Andrew D.¹²³⁴⁵,Smith George Davey¹²³⁴⁵,Hattersley Andrew T.¹²³⁴⁵,McCarthy Mark I.¹²³⁴⁵

Affiliation:

1. Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK.

2. Diabetes Genetics, Institute of Biomedical and Clinical Science, Peninsula Medical School, Barrack Road, Exeter, UK.

3. Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK.

4. MRC Centre for Causal Analyses in Translational Epidemiology, Bristol University, Canynge Hall, Whiteladies Road, Bristol, UK.

5. Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK.

Abstract

Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetesâsusceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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