Obesity-associated variants within FTO form long-range functional connections with IRX3-Reference-Cited by-同舟云学术

Obesity-associated variants within FTO form long-range functional connections with IRX3

Published:2014-03-12 Issue:7492 Volume:507 Page:371-375
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Smemo Scott,Tena Juan J.,Kim Kyoung-Han,Gamazon Eric R.,Sakabe Noboru J.,Gómez-Marín Carlos,Aneas Ivy,Credidio Flavia L.,Sobreira Débora R.,Wasserman Nora F.,Lee Ju Hee,Puviindran Vijitha,Tam Davis,Shen Michael,Son Joe Eun,Vakili Niki Alizadeh,Sung Hoon-Ki,Naranjo Silvia,Acemel Rafael D.,Manzanares Miguel,Nagy Andras,Cox Nancy J.,Hui Chi-Chung,Gomez-Skarmeta Jose Luis,Nóbrega Marcelo A.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature13138.pdf

Reference50 articles.

1. Dina, C. et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nature Genet. 39, 724–726 (2007)

2. Frayling, T. M. et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316, 889–894 (2007)

3. Scuteri, A. et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 3, e115 (2007)

4. Church, C. et al. Overexpression of Fto leads to increased food intake and results in obesity. Nature Genet. 42, 1086–1092 (2010)

5. Fischer, J. et al. Inactivation of the Fto gene protects from obesity. Nature 458, 894–898 (2009)

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