Cimetidine—A Non-Thiourea H2-Receptor Antagonist-Reference-Cited by-同舟云学术

Cimetidine—A Non-Thiourea H2-Receptor Antagonist

Published:1975-03 Issue:2 Volume:3 Page:86-92
ISSN:0300-0605
Container-title:Journal of International Medical Research
language:en
Short-container-title:J Int Med Res

Author:

Brimblecombe R W¹,Duncan W A M¹,Durant G J¹,Emmett J C¹,Ganellin C R¹,Parsons M E¹

Affiliation:

1. The Research Institute. Smith. Kline & French Laboratories Ltd, Welwyn Garden City, Hertfordshire. England

Abstract

Cimetidine is a non-thiourea analogue of metiamide. It is a specific competitive histamine H2-receptor antagonist and is an effective inhibitor of gastric secretion in animals and man with similar pharmacological properties to metiamide. No renal damage or haematological changes were observed in 90-day studies in rats or dogs.

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/030006057500300205

Reference6 articles.

1. RECEPTORS MEDIATING SOME ACTIONS OF HISTAMINE

2. Definition and Antagonism of Histamine H2-receptors

3. Metiamide — An orally active histamine H2-receptor antagonist

4. INHIBITION OF NOCTURNAL ACID SECRETION IN DUODENAL ULCER BY ONE ORAL DOSE OF METIAMIDE

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