Affiliation:
1. Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran
Abstract
Abstract:
In this work, we used a highly efficient and easy approach for synthesizing imidazolecarboxylate
salt through the reaction between α-amidino carboxylic acids and α-halo ketones with as readily
available starting materials in the presence of KHCO3 at THF under reflux. Targeted synthesis of
this type of imidazole bearing the carboxylic acid group in a single structure, in addition to the biological
properties enriched as a ligand, is very popular in the manufacture of catalysts. The salient features
of this protocol include eco-friendly, high atom-economical, easy and mild conditions that led to the
production of all products with high yields. Furthermore, all products were purified without the need
for column chromatography through the GAP chemistry (group-assisted purification chemistry) technique.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry