Synthesis, antioxidant activity, antimicrobial efficacy and molecular docking studies of 4-chloro-2-(1-(4-methoxyphenyl)-4,5-diphenyl-1H-imidazol-2-yl)phenol and its transition metal complexes

Author:

Ahmad Muhammad Saeed1,Siddique Abu Bakar1ORCID,Khalid Muhammad23ORCID,Ali Akbar4ORCID,Shaheen Muhammad Ashraf1,Tahir Muhammad Nawaz5,Imran Muhammad6ORCID,Irfan Ahmad67,Khan Muhammad Usman8ORCID,Paixão Marcio Weber9ORCID

Affiliation:

1. Institute of Chemistry, University of Sargodha, Sargodha, 40100, Pakistan

2. Institute of Chemistry, Khwaja Fareed University of Engineering & Information Technology, Rahim Yar Khan, 64200, Pakistan

3. Centre for Theoretical and Computational Research, Khwaja Fareed University of Engineering & Information Technology, Rahim Yar Khan, 64200, Pakistan

4. Department of Chemistry, Government College University Faisalabad, Faisalabad 38000, Pakistan

5. Department of Physics, University of Sargodha, Sargodha, Pakistan

6. Department of Chemistry, College of Science, King Khalid University, PO. Box 9004, Abha 61413, Saudi Arabia

7. Research Center for Advanced Materials Science (RCAMS), King Khalid University, PO. Box 9004, Abha 61413, Saudi Arabia

8. Department of Chemistry, University of Okara, Okara-56300, Pakistan

9. Department of Chemistry, Universidade Federal de São Carlos (UFSCar), São Carlos, SP, Brazil

Abstract

Herein, a one-pot synthesis of tetra-substituted imidazole, 4-chloro-2-(1-(4-methoxyphenyl)-4,5-diphenyl-1H-imidazol-2-yl)phenol (HL), is reported by the reaction of benzil, 5-chlorosalicylaldehyde, ammonium acetate and anisidine.

Funder

King Khalid University

Higher Education Commission, Pakistan

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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