Synthesis, Characterization, and Antibacterial Studies of New Cu(II) and Pd(II) Complexes with 6-Methyl-2-Thiouracil and 6-Propyl-2-Thiouracil-Reference-Cited by-同舟云学术

Synthesis, Characterization, and Antibacterial Studies of New Cu(II) and Pd(II) Complexes with 6-Methyl-2-Thiouracil and 6-Propyl-2-Thiouracil

Published:2023-12-11 Issue:24 Volume:13 Page:13150
ISSN:2076-3417
Container-title:Applied Sciences
language:en
Short-container-title:Applied Sciences

Author:

Marinova Petya¹^ORCID,Hristov Mariyan¹,Tsoneva Slava²,Burdzhiev Nikola³^ORCID,Blazheva Denica⁴^ORCID,Slavchev Aleksandar⁴,Varbanova Evelina²,Penchev Plamen²

Affiliation:

1. Department of General and Inorganic Chemistry with Methodology of Chemistry Education, Faculty of Chemistry, “Tzar Assen” Str. 24, 4000 Plovdiv, Bulgaria

2. Department of Analytical Chemistry and Computer Chemistry, Faculty of Chemistry, University of Plovdiv, “Tzar Asen” Str. 24, 4000 Plovdiv, Bulgaria

3. Department of Organic Chemistry and Pharmacognosy, Faculty of Chemistry and Pharmacy, University of Sofia, 1, J. Bourchier Av., 1164 Sofia, Bulgaria

4. Department of Microbiology, University of Food Technologies, 26 Maritza Blvd., 4002 Plovdiv, Bulgaria

Abstract

The aim of the present study is to synthesize new metal complexes of 6-methyl-2-thiouracil and 6-propyl-2-thiouracil, elucidate their structures, and investigate their biological properties. All metal complexes were obtained after mixing water solutions of the corresponding metal salts and the ligand dissolved in DMSO and water solutions of NaOH in a metal-to-ligand ratio of 1:4:2. The structures of the new compounds are discussed based on melting point analysis (MP-AES) for Cu and Pd, UV-Vis, IR, ATR, 1H NMR, 13C NMR, and Raman spectroscopy. The interpretation of complex spectra is assisted by the data for 6-methyl-2-thiouracil and 6-propyl-2-thiouracil obtained from 1H-1H COSY, DEPT-135, HMBC and HMQC spectra. In addition, the antimicrobial activity of these complexes and the free ligands are assessed against both Gram-positive and Gram-negative bacteria, as well as yeasts. In general, the addition of metal ions improved the antimicrobial activity of both 6-methyl-2-thiouracil and 6-propyl-2-thiouracil. The Cu(II) complex with 6-methyl-2-thiouracil and the Pd(II) complex with 6-propyl-2-thiouracil exhibited the highest activity against the test microorganisms.

Funder

Fund for Scientific Research of the Plovdiv University

Publisher

MDPI AG

Subject

Fluid Flow and Transfer Processes,Computer Science Applications,Process Chemistry and Technology,General Engineering,Instrumentation,General Materials Science

Link

https://www.mdpi.com/2076-3417/13/24/13150/pdf

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