Experimental Viral Pneumonia in Guinea Pigs: An Ultrastructural Study

Author:

Kaup F.-J.1,Naumann S.1,Kunstyr I.1,Drommer W.1

Affiliation:

1. Institut für Pathologie, Tierärztliche Hochschule Hannover, and Institut für Versuchstierkunde und Zentrales Tierlabor, Medizinische Hochschule Hannover, West Germany

Abstract

Homogenized lung tissue was used to experimentally reproduce lethal viral pneumonia in guinea pigs. The resultant lesions corresponded with those of the spontaneous disease. Pneumonia with necrotic bronchiolar epithelium accompanied by basophilic intranuclear inclusion bodies was the primary finding. With transmission electron microscopy, numerous viral particles were found—mainly within the nucleus of pulmonary epithelial cells but also within the cytoplasm and in extracellular space. The appearance of viral particles, in particular their paracrystalline and crystalline deposition within the nucleus, indicates that our experimentally induced pneumonia was caused by an adenovirus.

Publisher

SAGE Publications

Subject

General Veterinary

Cited by 6 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Respiratory Diseases in Guinea Pigs, Chinchillas and Degus;Veterinary Clinics of North America: Exotic Animal Practice;2021-05

2. Adenovirus pneumonia in guinea pigs;Australian Veterinary Journal;1999-03

3. Implications of infectious agents on results of animal experiments;Laboratory Animals;1999-01

4. Polymerase Chain Reaction for Detection of Guinea Pig Adenovirus;Journal of Veterinary Diagnostic Investigation;1997-07

5. Experimental pneumonia virus of mice infection of guineapigs spontaneously infected with Bordetella bronchiseptica;Laboratory Animals;1997-01-01

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