Synthesis of 3-(2-oxopropyl)-2-arylisoindolinone derivatives via a three-component reaction of diaryliodonium salts with 2-formylbenzonitriles and phenylacetylenes

Abstract

A copper-catalyzed multicomponent cascade cyclization using readily available substrates, including 2-formylbenzonitriles, phenylacetylenes, and diaryliodonium salts, is achieved. A broad reaction scope is presented with good functional group compatibility, giving rise to a range of 3-(2-oxopropyl)-2-arylisoindolinones in moderate to good yields.