3-Oxoisoindoline-1-carboxamides: Potent, State-Dependent Blockers of Voltage-Gated Sodium Channel NaV1.7 with Efficacy in Rat Pain Models-Reference-Cited by-同舟云学术

3-Oxoisoindoline-1-carboxamides: Potent, State-Dependent Blockers of Voltage-Gated Sodium Channel NaV1.7 with Efficacy in Rat Pain Models

Published:2012-07-23 Issue:15 Volume:55 Page:6866-6880
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Macsari Istvan,Besidski Yevgeni,Csjernyik Gabor,Nilsson Linda I.,Sandberg Lars,Yngve Ulrika,Åhlin Kristofer,Bueters Tjerk,Eriksson Anders B.,Lund Per-Eric,Venyike Elisabet,Oerther Sandra,Hygge Blakeman Karin,Luo Lei,Arvidsson Per I.¹²

Affiliation:

1. Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, Uppsala Biomedical Centre, Uppsala University, Box 574, SE-751 23 Uppsala, Sweden

2. School of Pharmacy and Pharmacology, Westville Campus, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300623u

Reference49 articles.

1. International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels

2. A stop codon mutation in SCN9A causes lack of pain sensation

3. An SCN9A channelopathy causes congenital inability to experience pain

4. Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations

5. Two novel mutations of SCN9A (Nav1.7) are associated with partial congenital insensitivity to pain

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