Recent Advancements in Trifluoromethylation Strategies for Indoles, Oxindoles and Indolines

Abstract

AbstractFluorine being a magic element and Indole being a magic molecule, their cumulative effect has tremendously increased the potential of resulting moiety for drug development. Keeping this in mind, we are describing a comprehensive account on the recent strategies for the synthesis of trifluoromethylated indoles, indoline and oxindoles. In this review we have explored two types of strategies for trifluoromethylation reactions, one involves direct installation of CF3 group at indole moiety via C−H activation and substitution where as other is by the cyclization reaction of the starting compound containing CF3 group. The reactions were explored for the substrate scope and mechanism using controlled experiments.