Immunostimulatory Activity of Black Rice Bran in Cyclophosphamide-Induced Immunosuppressed Rats

Author:

Park Young Mi1,Lee Hak Yong1,Shin Dong Yeop1,Lee Yang Hee1,Yang Ye Jin1,Lee Hae Seong1,Lee Jung O2,Choi Kyeong Suk2,Kang Ji Hyun2,Cho Young Ho2,Kim Min Guk3,Yun Chi Young3,Kim Min Jung4,Jang Dai Ja4,Yang Hye Jeong4,Lee Young-Rae15ORCID

Affiliation:

1. INVIVO Co. Ltd., Iksan, Jeonbuk, Republic of Korea

2. Jarm Agricultural Co. Ltd., Jindo-gun, Jeollanam-do, Republic of Korea

3. Chungju City Hall, Chunju-si, Chungcheongbuk-do, Republic of Korea

4. Korea Food Research Institute, Wanju-gun, Jeollabuk-do, Republic of Korea

5. Department of Oral Biochemistry, and Institute of Biomaterial-Implant College of Dentistry, Wonkwang University, Iksan, Jeonbuk, Republic of Korea

Abstract

Black rice bran extract (BRBE), containing various biologically active compounds, such as anthocyanin, has antioxidant activity and numerous pharmacological effects. Here, we aimed to confirm the immunostimulatory effects of BRBE in cyclophosphamide (CP)-induced immunosuppressed cells. Our results confirmed that BRBE exerted an immunostimulatory effect. In vitro, BRBE treatment enhanced cell proliferation, activity of natural killer cells and cytotoxic T lymphocytes, and production of CP-repressed cytokines, such as tumor necrosis factor-α, interferon-γ, interleukin (IL)-2, and IL-12, and immunoglobulins G and A in isolated splenocytes. Additionally, in vivo, BRBE treatment increased the number of immune cells, such as white blood cells, lymphocyte counts, mid-range absolute counts, and neutrophils in CP-induced immunosuppressed rats. Furthermore, BRBE increased the serum levels of abovementioned inflammatory cytokines and immunoglobulins in CP-induced immunosuppressed rats. In addition, BRBE protected against CP-mediated spleen and thymic tissue damage. Our findings suggest that BRBE could be potentially used as a component of functional food for immunity enhancement.

Funder

the Ministry of Agriculture, Food and Rural Affairs and National Research Council of Science & Technology (NST) grant by the Korea Government

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

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