Microbial Biotransformation of 16α,17-Epoxy-Ent-kaurane-19-oic acid by Beauveria Sulfurescens ATCC 7159-F

Author:

Furtado Ricardo A.12,Gunaherath G. M. Kamal B.1,Bastos Jairo K.2,Gunatilaka A. A. Leslie1

Affiliation:

1. SW Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona, 250 E. Valencia Road, Tucson, Arizona 85706–6800, USA

2. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café S/N, Ribeirão Preto, São Paulo, Brazil, 14040–903

Abstract

Biotransformation of 16α,17-epoxy- ent-kaurane-19-oic acid (1) by Beauveria sulfurescens ATCC 7159-F led to the production of a new ent-kaurane diterpenoid, 7β,17-dihydroxy- ent-kaur-15-en-19-oic acid (7), and four other ent-kauranes (8 - 11), all of which were identified as their methyl esters. Compounds 9 and 10 were found to be new stereoisomers. Structures of these were established by the extensive usage of their spectroscopic characteristics.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

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