1. Department of Medicinal Chemistry, Department of Pharmaceutics, and Graduate Institute of Pharmacognosy Science, College of Pharmacy, Taipei Medical University, Taipei, Taiwan 11031, Graduate Institute of Cell and Molecular Biology and Graduate Institute of Neuroscience, College of Medicine, Taipei Medical University, Taipei, Taiwan 11031, and Division of Medicinal Chemistry, National Research Institute of Chinese Medicine, Taipei, Taiwan 11221, Republic of China