Abstract
AbstractC–H bond oxidation is a powerful means for oxygen incorporation in organic molecules. Its use results in fast structural diversification and in a new way of thinking about retrosynthetic disconnections. In this review, we present the application of five metal-catalyzed methodologies for C(sp
3)–H oxidation in the total synthesis of natural and unnatural products, covering the period of 2004–2022.1 Introduction2 Copper-Mediated Hydroxylation of Methylenes β to Imines3 Palladium Acetoxylation of Methyl Groups β to Oximes4 Palladium-Mediated Allylic C–H Bond Oxidation of Terminal Olefins5 Iron- and Manganese-Mediated Aliphatic Oxidation6 Miscellaneous7 Conclusion
Funder
Fundação de Amparo à Pesquisa do Estado de São Paulo
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Fundo de Apoio ao Ensino, à Pesquisa e Extensão, Universidade Estadual de Campinas
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Subject
Organic Chemistry,Catalysis
Cited by
9 articles.
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