A New Phenolic Diterpene From the Leaves of Rosmarinus officinalis

Author:

Zhang Tingwen1,Zhao Deng-Gao12ORCID,Li Shuting1,Zhang Kun12,Yang Mei-Li3,Huang Xuan1,Li Leyi1,Ma Yan-Yan12

Affiliation:

1. School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China

2. International Healthcare Innovation Institute (Jiangmen), Jiangmen, China

3. Baoji University of Arts and Sciences, Baoji, China

Abstract

As part of our continuous studies on dietary supplements for diabetes, 1 new phenolic diterpene, 7-butoxyrosmanol (1), and 3 known ones (2-4) were isolated from Rosmarinus officinalis. The new structure was elucidated based on comprehensive spectroscopic methods, including multiple nuclear magnetic resonance techniques, mass spectrometry, and x-ray diffraction analysis. In addition, compound 1 showed moderate activity against pancreatic lipase with an IC50 value of 46.2 μM.

Funder

Scientific Research Foundation of Shaanxi Provincial Key Laboratory

the Department of Education of Guangdong Province

Jiangmen Program for Innovative Research Team

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

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