Cytotoxic and Antimalarial Alkaloids from the Twigs of Dasymaschalon obtusipetalum-Reference-Cited by-同舟云学术

Cytotoxic and Antimalarial Alkaloids from the Twigs of Dasymaschalon obtusipetalum

Published:2015-07 Issue:7 Volume:10 Page:1934578X1501000
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Jaidee Atchara¹,Promchai Thanika¹,Trisuwan Kongkiat¹,Laphookhieo Surat²,Rattanajak Roonglawan³,Kamchonwongpaisan Sumalee³,Pyne Stephen G.⁴,Ritthiwigrom Thunwadee¹

Affiliation:

1. Department of Chemistry, Faculty of Science, Chiang Mai University, Sutep, Muang, Chiang Mai 50200, Thailand

2. Natural Products Research Laboratory, School of Science, Mae Fah Luang University, Tasud, Muang, Chiang Rai 57100, Thailand

3. Medical Molecular Biology Research Unit, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Thailand Science Park, Pathumthani 12120, Thailand

4. School of Chemistry, University of Wollongong, Wollongong, New South Wales 2522, Australia

Abstract

One new p-quinonoid aporphine alkaloid, obtusipetadione (1), and eleven known compounds (2–12) were isolated from the acetone extract of the twigs of Dasymaschalon obtusipetalum. Their structures were elucidated by spectroscopic methods. The cytotoxic and antimalarial activities of the isolated compounds were evaluated. Compound 1 showed significant in vitro antiplasmodial activity against the P. falciparum strains TM4 and K1 (multidrug resistant strain) with IC50 values of 2.46±0.12 and 1.38±0.99 μg/mL, respectively with no cytotoxicity. Compound 9 had more modest antiplasmodial activity, but significant cytotoxicity.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1501000709

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