Cytotoxic Alkaloids from Leaves and Twigs of Dasymaschalon sootepense-Reference-Cited by-同舟云学术

Cytotoxic Alkaloids from Leaves and Twigs of Dasymaschalon sootepense

Published:2014-07 Issue:7 Volume:9 Page:1934578X1400900
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Hongthong Sakchai¹,Kuhakarn Chutima¹,Reutrakul Vichai¹,Jariyawat Surawat²,Piyachaturawat Pawinee²,Nuntasaen Narong³,Jaipetch Thaworn⁴

Affiliation:

1. Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand

2. Department of Physiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand

3. The Forest Herbarium National Park, Wildlife and Plant Conservation Department, Ministry of Natural Resources and Environment, Bangkok, Thailand

4. Mahidol University, Kanchanaburi Campus, Saiyok, Kanchanaburi 71150, Thailand

Abstract

Bioassay-guided fractionation of the cytotoxic ethyl acetate fraction of the sequential methanol extract from the leaves and twigs of Dasymaschalon sootepense led to the isolation of a new 7-hydroxy aporphine alkaloid, 6a,7-dehydrodasymachaline (1) along with the five known compounds (-)-nordicentrine (2), dicentrinone (3), (-)-sinactine (4), aristolactam AII (5) and epiberberine (6). Their structures were elucidated by spectroscopic methods. This is the first report of alkaloids 1–2 and 5–6 from the genus Dasymaschalon. Compounds 1 and 5 showed cytotoxicity against a panel of cancer cell lines.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1400900711

Reference34 articles.

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