Magnetisation transfer ratio abnormalities in primary and secondary progressive multiple sclerosis-Reference-Cited by-同舟云学术

Magnetisation transfer ratio abnormalities in primary and secondary progressive multiple sclerosis

Published:2019-04-08 Issue:6 Volume:26 Page:679-687
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Brown James William L¹^ORCID,Chowdhury Azmain²,Kanber Baris³,Prados Carrasco Ferran⁴,Eshaghi Arman²,Sudre Carole H⁵,Pardini Matteo⁶,Samson Rebecca S²^ORCID,van de Pavert Steven HP²,Wheeler-Kingshott Claudia Gandini⁷,Chard Declan T⁸^ORCID

Affiliation:

1. NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, UK/Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK

2. NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, UK

3. NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, UK/Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London, UK/National Institute for Health Research (NIHR) Biomedical Research Centre, University College London Hospitals (UCLH), London, UK/Department of Clinical and Experimental Epilepsy, UCL Queen Square...

4. NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, UK/Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London, UK/eHealth Center, Universitat Oberta de Catalunya, Barcelona, Spain

5. Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London, UK/Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK/School of Biomedical Engineering & Imaging Sciences, King’s College London, London, UK

6. NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, UK/Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, and IRCCS AOU San Martino-IST, Genoa, Italy

7. NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, UK/Brain MRI 3T Mondino Research Center, IRCCS Mondino Foundation, Pavia, Italy/Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy

8. NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, UK/National Institute for Health Research (NIHR) Biomedical Research Centre, University College London Hospitals (UCLH), London, UK

Abstract

Background: In relapse-onset multiple sclerosis (MS), tissue abnormality – as assessed with magnetisation transfer ratio (MTR) imaging – is greater in the outer cortical and inner periventricular layers. The cause of this remains unknown but meningeal inflammation has been implicated, particularly lymphoid follicles, which are seen in secondary progressive (SP) but not primary progressive (PP) MS. Cortical and periventricular MTR gradients might, therefore, differ in PPMS and SPMS if these follicles are responsible. Objective: We assessed cortical and periventricular MTR gradients in PPMS, and compared gradients between people with PPMS and SPMS. Methods: Using an optimised processing pipeline, periventricular normal-appearing white matter and cortical grey-matter MTR gradients were compared between 51 healthy controls and 63 people with progressive MS (28 PPMS, 35 SPMS). Results: The periventricular gradient was significantly shallower in healthy controls (0.122 percentage units (pu)/band) compared to PPMS (0.952 pu/band, p < 0.0001) and SPMS (1.360 pu/band, p < 0.0001). The cortical gradient was also significantly shallower in healthy controls (−2.860 pu/band) compared to PPMS (−3.214 pu/band, p = 0.038) and SPMS (−3.328 pu/band, p = 0.016). Conclusion: Abnormal periventricular and cortical MTR gradients occur in both PPMS and SPMS, suggesting comparable underlying pathological processes.

Funder

Multiple Sclerosis Society

Publisher

SAGE Publications

Subject

Clinical Neurology,Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1352458519841810

Reference31 articles.

1. The natural history of multiple sclerosis: a geographically based study 9: Observations on the progressive phase of the disease

2. Identical lesion morphology in primary progressive and relapsing–remitting MS –an ultrahigh field MRI study

3. A comparison of the pathology of primary and secondary progressive multiple sclerosis

4. Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis

Cited by 13 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Increased periventricular thalamic damage gradient in multiple sclerosis detected by quantitative gradient echo MRI;Multiple Sclerosis and Related Disorders;2024-10

2. An update on the role of magnetic resonance imaging in predicting and monitoring multiple sclerosis progression;Expert Review of Neurotherapeutics;2024-01-18

3. Periventricular gradients in NAWM abnormalities differ in MS, NMOSD and MOGAD;Multiple Sclerosis and Related Disorders;2023-07

4. Periventricular remyelination failure in multiple sclerosis: a substrate for neurodegeneration;Brain;2022-09-13

5. The expansion and severity of chronic MS lesions follows a periventricular gradient;Multiple Sclerosis Journal;2022-03-16