Identical lesion morphology in primary progressive and relapsing–remitting MS –an ultrahigh field MRI study-Reference-Cited by-同舟云学术

Identical lesion morphology in primary progressive and relapsing–remitting MS –an ultrahigh field MRI study

Published:2014-04-29 Issue:14 Volume:20 Page:1866-1871
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Kuchling Joseph¹,Ramien Caren¹,Bozin Ivan¹,Dörr Jan²,Harms Lutz³,Rosche Berit³,Niendorf Thoralf⁴,Paul Friedemann⁵,Sinnecker Tim⁶,Wuerfel Jens⁷

Affiliation:

1. NeuroCure Clinical Research Center, Charité – Universitaetsmedizin Berlin, Germany

2. NeuroCure Clinical Research Center/Clinical and Experimental MS Research Center, Charité – Universitaetsmedizin Berlin, Berlin, Germany

3. Clinical and Experimental MS Research Center/Charité – Universitaetsmedizin Berlin, Berlin, Germany

4. Berlin Ultrahigh Field Facility (BUFF)/Experimental and Clinical Research Center, Charité – Universitaetsmedizin Berlin and Max Delbrueck Center for Molecular Medicine, Berlin, Germany

5. NeuroCure Clinical Research Center/Clinical and Experimental MS Research Center/Experimental and Clinical Research Center, Charité – Universitaetsmedizin Berlin and Max Delbrueck Center for Molecular Medicine, Berlin, Germany

6. NeuroCure Clinical Research Center, Charité - Universitaetsmedizin Berlin, Germany/Asklepios Fachklinikum Teupitz, Germany

7. NeuroCure Clinical Research Center/BUFF, Max Delbrueck Center for Molecular Medicine, Berlin, Germany/Experimental and Clinical Research Center, Charité – Universitaetsmedizin Berlin and Max Delbrueck Center for Molecular Medicine, Berlin/Institute of Neuroradiology, University Medicine Goettingen, Germany

Abstract

Potential differences between primary progressive (PP) and relapsing–remitting (RR) multiple sclerosis (MS) have been controversially discussed. In this study, we compared lesion morphology and distribution in patients with PPMS and RRMS (nine in each group) using 7 T MRI. We found that gray and white matter lesions in PPMS and RRMS patients did not differ in their respective morphological characteristics (e.g. perivascular p = 0.863, hypointense rim p = 0.796, cortical lesion count p = 0.436). Although limited by a small sample size, our study results suggest that PPMS and RRMS, despite differences in disease course and clinical characteristics, exhibit identical lesion morphology under ultrahigh field MRI.

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1352458514531084

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