Chemopreventive Effect of Sarcophine-diol on NOR-1-Induced TPA-Promoted Skin Carcinogenesis in Female HOS:HR-1 Mice-Reference-Cited by-同舟云学术

Chemopreventive Effect of Sarcophine-diol on NOR-1-Induced TPA-Promoted Skin Carcinogenesis in Female HOS:HR-1 Mice

Published:2013-02 Issue:2 Volume:8 Page:1934578X1300800
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Szymanski Pawel T.¹,Ahmed Safwat A.²,Khalifa Sherief³,Tokuda Harukuni⁴,Ichiishi Eiichiro⁵,Iida Akira⁶,Suzuki Nobutaka⁴,Fahmy Hesham¹

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD 57007, USA

2. Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt

3. College of Pharmacy, Qatar University, Doha 02713, Qatar

4. Department of Complementary and Alternative Medicine, Clinical R&D, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan 920-8640

5. International University of Health and Welfare Hospital, Tochigi, Japan 329-2763

6. Faculty of Agriculture, Kinki University, Nara, Japan 631-8505

Abstract

The cancer chemopreventive potential of sarcophine-diol in a chemical carcinogen initiation–promotion experimental tumor model in mice was evaluated. Sarcophine-diol, when given orally, afforded significant protection in the mouse skin cancer model initiated by the topical administration of (±)-( E)-4-methyl-2-[( E)-hydroxyamino]-5-nitro-6-methoxy-3-hexanamide (NOR-1) and promoted by 12- O-tetradecanoylphorbol-13-acetate (TPA). These findings, along with our initial reports, suggest that sarcophine-diol is an effective cancer chemopreventive agent, even when administered orally and at a very low dose and thus indicating possible potential human applications in the control of malignancy.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1300800203

Reference15 articles.

1. Novel Marine Phenazines as Potential Cancer Chemopreventive and Anti-Inflammatory Agents

2. Anticancer and Anti-inflammatory Sulfur-Containing Semisynthetic Derivatives of Sarcophine

3. Marine Antitumor Drugs: Status, Shortfalls and Strategies

4. Antitumor Compounds from Marine Actinomycetes

5. Semisynthesis of New Sarcophine Derivatives with Chemopreventive Activity

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