Evaluation of Anti-melanoma Activities of (1S,2E,4R,6E,8R,11S,12R)-8,12-epoxy-2,6-cembradiene-4,11-diol, (1S,2E,4R,6E,8S,11R,12S)-8,11-epoxy-4,12-epoxy-2,6-cembradiene and (1S,4R,13S)-cembra-2E,7E,11E-trien-4,13-diol from the Red Sea soft coral Sarcophyton glaucum
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Published:2014-08
Issue:8
Volume:9
Page:1934578X1400900
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ISSN:1934-578X
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Container-title:Natural Product Communications
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language:en
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Short-container-title:Natural Product Communications
Author:
Szymanski Pawel T.1, Ahmed Safwat A.2, Radwan Mohamed M.34, Khalifa Sherief I.5, Fahmy Hesham1
Affiliation:
1. Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD 57007, USA 2. Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt 3. National Center for Natural Products Center, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA 4. Department of Pharmacognosy, Faculty of Pharmacy, University of Alexandria, Alexandria 21521, Egypt 5. College of Pharmacy, Qatar University, Doha 02713, Qatar9
Abstract
Three natural cembranoids from the Red Sea soft coral Sarcophyton glaucum namely (1 S,2 E,4 R,6 E,8 R,11 S,12 R)-8,12-epoxy-2,6-cembradiene-4,11-diol, (1 S,2 E,4 R,6 E,8 S,11 R,12 S)-8,11-epoxy-4,12-epoxy-2,6-cembradiene and (1 S,4 R,13 S)-cembra-2 E,7 E,11 E-trien-4,13-diol were evaluated for their inhibitory effects on mouse melanoma B16F10 cell growth. Results show that all the cembranoids strongly inhibit viability of melanoma cells particularly during 48–72 hrs treatment and also inhibit de novo DNA synthesis and PARP activity and stimulate fragmentation of DNA. (1 S,2 E,4 R,6 E,8 R,11 S,12 R)-8,12-epoxy-2,6-cembradiene-4,11-diol was not cytotoxic to monkey kidney CV-1 cells at the concentration that produces the anti-melanoma effects which indicates that this compound may be a good candidate for further development. (1 S,2 E,4 R,6 E,8 S,11 R,12 S)-8,11-epoxy-4,12-epoxy-2,6-cembradiene and (1 S,4 R,13 S)-cembra-2 E,7 E,11 E-trien-4,13-diol were found to be cytotoxic to healthy cells.
Publisher
SAGE Publications
Subject
Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine
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