An Expeditious, Multi-gram Isolation Protocol for the Ultrapotent SERCA Inhibitor Thapsigargin-Reference-Cited by-同舟云学术

An Expeditious, Multi-gram Isolation Protocol for the Ultrapotent SERCA Inhibitor Thapsigargin

Published:2007-06 Issue:6 Volume:2 Page:1934578X0700200
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Pagani Alberto¹²,Pollastro Federica¹²,Spera Silvia³,Ballero Mauro²,Sterner Olov⁴,Appendino Giovanni¹²

Affiliation:

1. Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Via Bovio 6, 28100 Novara, Italy

2. Consorzio per lo Studio dei Metaboliti Secondari (COSMESE), Viale S. Ignazio 13, 09123 Cagliari, Italy

3. ENI S.p.A., Istituto di Chimica Guido Donegani, Via G. Fauser 4, 28100 Novara, Italy

4. Department of Organic Chemistry, Lund University, P.O. Box 124, 221 00 Lund, Sweden

Abstract

A streamlined strategy was developed to obtain a mixture of thapsigargins from the fruits of Thapsia garganica L. The mixture was resolved by RP-silica gel flash chromatography to provide, after trituration with ether, 0.32% thapsigargin (1a) as a white powder. A novel, complex phenylpropanoid (neohelmanthicin D, 2a) was also obtained, and its structure confirmed by semisynthesis.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X0700200604

Reference14 articles.

1. For reviews, see: (a) AvatoP. (1997) The genus Thapsia as a source of bioactive compounds, in Virtual Activity, Real Pharmacology (VerottaL. Ed.), Research Signpost, Trivandrum, p. 17–31

2. Structural Basis of Ion Pumping by Ca2+-ATPase of the Sarcoplasmic Reticulum

3. Design, Synthesis, and Pharmacological Evaluation of Thapsigargin Analogues for Targeting Apoptosis to Prostatic Cancer Cells

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