Design, Synthesis, and Pharmacological Evaluation of Thapsigargin Analogues for Targeting Apoptosis to Prostatic Cancer Cells-Reference-Cited by-同舟云学术

Design, Synthesis, and Pharmacological Evaluation of Thapsigargin Analogues for Targeting Apoptosis to Prostatic Cancer Cells

Published:2001-11-22 Issue:26 Volume:44 Page:4696-4703
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jakobsen Carsten M.¹,Denmeade Samuel R.¹,Isaacs John T.¹,Gady Alyssa¹,Olsen Carl E.¹,Christensen Søren Brøgger¹

Affiliation:

1. Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, 2 Universitetsparken, DK-2100 Copenhagen, Denmark, Department of Experimental Therapeutics, Johns Hopkins Oncology Center, Bunting-Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, Maryland 21231, USA, and Chemistry Department, The Royal Veterinary and Agricultural University, 17 Bülowsvej, DK-1870 Frederiksberg, Denmark

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm010985a

Reference21 articles.

1. Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

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