Bat Red Blood Cells Express Nucleic Acid–Sensing Receptors and Bind RNA and DNA

Author:

Lam L. K. Metthew1ORCID,Dobkin Jane1,Eckart Kaitlyn A.1,Gereg Ian2,DiSalvo Andrew3ORCID,Nolder Amber3,Anis Eman2,Ellis Julie C.2,Turner Greg3ORCID,Mangalmurti Nilam S.14ORCID

Affiliation:

1. *Division of Pulmonary, Allergy and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA;

2. †Department of Pathobiology, Wildlife Futures Program, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA;

3. ‡Bureau of Wildlife Management, Pennsylvania Game Commission, Harrisburg, PA; and

4. §Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

Abstract

Abstract RBCs demonstrate immunomodulatory capabilities through the expression of nucleic acid sensors. However, little is known about bat RBCs, and no studies have examined the immune function of bat erythrocytes. In this study, we show that bat RBCs express the nucleic acid–sensing TLRs TLR7 and TLR9 and bind the nucleic acid ligands, ssRNA, and CpG DNA. Collectively, these data suggest that, like human RBCs, bat erythrocytes possess immune function and may be reservoirs for nucleic acids. These findings provide unique insight into bat immunity and may uncover potential mechanisms by which virulent pathogens of humans are concealed in bats.

Publisher

The American Association of Immunologists

Subject

Immunology and Allergy,General Medicine,Immunology

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