Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA-Reference-Cited by-同舟云学术

Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

Published:2004-03-05 Issue:5663 Volume:303 Page:1529-1531
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Diebold Sandra S.¹²³⁴,Kaisho Tsuneyasu¹²³⁴,Hemmi Hiroaki¹²³⁴,Akira Shizuo¹²³⁴,Reis e Sousa Caetano¹²³⁴

Affiliation:

1. Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK.

2. Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3-1, Suita City, Osaka 565–0871, Japan.

3. RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumiku, Yokohama City, Kanagawa 230–0045, Japan.

4. Akira Innate Immunity Project, ERATO, Japan Science and Technology Corporation, Osaka 565–0871, Japan.

Abstract

Interferons (IFNs) are critical for protection from viral infection, but the pathways linking virus recognition to IFN induction remain poorly understood. Plasmacytoid dendritic cells produce vast amounts of IFN-α in response to the wild-type influenza virus. Here, we show that this requires endosomal recognition of influenza genomic RNA and signaling by means of Toll-like receptor 7 (TLR7) and MyD88. Single-stranded RNA (ssRNA) molecules of nonviral origin also induce TLR7-dependent production of inflammatory cytokines. These results identify ssRNA as a ligand for TLR7 and suggest that cells of the innate immune system sense endosomal ssRNA to detect infection by RNA viruses.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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