DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia

Author:

Lam L. K. Metthew12ORCID,Murphy Sophia1,Kokkinaki Dimitra1ORCID,Venosa Alessandro3ORCID,Sherrill-Mix Scott24ORCID,Casu Carla5,Rivella Stefano5ORCID,Weiner Aaron6ORCID,Park Jeongho7ORCID,Shin Sunny48ORCID,Vaughan Andrew E.6ORCID,Hahn Beatrice H.24,Odom John Audrey R.9ORCID,Meyer Nuala J.128ORCID,Hunter Christopher A.78,Worthen G. Scott810ORCID,Mangalmurti Nilam S.128ORCID

Affiliation:

1. Division of Pulmonary, Allergy and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

3. Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA.

4. Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

5. Division of Hematology, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

6. Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.

7. Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.

8. Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

9. Division of Infectious Diseases, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

10. Division of Neonatalogy, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

Abstract

Red blood cells detect and bind cell-free nucleic acids, contributing to anemia and immune cell activation during acute inflammation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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