DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia-Reference-Cited by-同舟云学术

DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia

Published:2021-10-20 Issue:616 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Lam L. K. Metthew¹²^ORCID,Murphy Sophia¹,Kokkinaki Dimitra¹^ORCID,Venosa Alessandro³^ORCID,Sherrill-Mix Scott²⁴^ORCID,Casu Carla⁵,Rivella Stefano⁵^ORCID,Weiner Aaron⁶^ORCID,Park Jeongho⁷^ORCID,Shin Sunny⁴⁸^ORCID,Vaughan Andrew E.⁶^ORCID,Hahn Beatrice H.²⁴,Odom John Audrey R.⁹^ORCID,Meyer Nuala J.¹²⁸^ORCID,Hunter Christopher A.⁷⁸,Worthen G. Scott⁸¹⁰^ORCID,Mangalmurti Nilam S.¹²⁸^ORCID

Affiliation:

1. Division of Pulmonary, Allergy and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

3. Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA.

4. Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

5. Division of Hematology, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

6. Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.

7. Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.

8. Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

9. Division of Infectious Diseases, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

10. Division of Neonatalogy, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

Abstract

Red blood cells detect and bind cell-free nucleic acids, contributing to anemia and immune cell activation during acute inflammation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference61 articles.

1. Identification of a promiscuous inflammatory peptide receptor on the surface of red blood cells

2. Red blood cells are a sink for interleukin 8, a leukocyte chemotaxin.

3. The Immune-Adherence Phenomenon

4. Red Blood Cells Homeostatically Bind Mitochondrial DNA through TLR9 to Maintain Quiescence and to Prevent Lung Injury

5. A Toll-like receptor recognizes bacterial DNA

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