Telomere-telomerase system status in patients with acute myocardial infarction with ST-segment elevation (STEMI) -relationship with oxidative stress-Reference-Cited by-同舟云学术

Telomere-telomerase system status in patients with acute myocardial infarction with ST-segment elevation (STEMI) -relationship with oxidative stress

Published:2021-04-30 Issue: Volume: Page:
ISSN:1734-1922
Container-title:Archives of Medical Science
language:
Short-container-title:Arch Med Sci

Author:

Vukašinović Aleksandra¹,Ostanek Barbara²,Klisic Aleksandra³^ORCID,Kafedžić Srdjan⁴,Zdravković Marija⁵,Ilić Ivan⁴,Sopić Miron¹,Hinić Saša⁶,Stefanović Milica⁷,Memon Lidija⁸,Gaković Branka⁷,Bogavac-Stanojević Nataša¹,Spasojević-Kalimanovska Vesna¹,Marc Janja²,Nešković Aleksandar⁴,Kotur-Stevuljević Jelena¹

Affiliation:

1. Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia

2. Department of Clinical Biochemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia

3. Primary Health Care Center, University of Montenegro-Faculty of Medicine, Podgorica, Montenegro

4. Department of Cardiology, Clinical Hospital Center Zemun, Belgrade, Serbia Faculty of Medicine, University of Belgrade, Belgrade, Serbia

5. Faculty of Medicine, University of Belgrade, Belgrade, Serbia Department of Cardiology, Clinical Hospital Center Bezanijska kosa, Belgrade, Serbia

6. Department of Cardiology, Clinical Hospital Center Bezanijska kosa, Belgrade, Serbia

7. Department of Cardiology, Clinical Hospital Center Zemun, Belgrade, Serbia

8. Clinical Hospital Center Bezanijska kosa, Clinical Chemistry Laboratory, Belgrade, Serbia

Abstract

IntroductionWe aimed to find association of telomere length and telomerase activity in circulating leukocytes and thromboaspirates of patients with acute myocardial infarction (AMI). Furthermore, association of telomere-telomerase system with oxidative stress markers was tested.Material and methodsLeukocyte telomere length, telomerase activity and scores related to oxidative-stress status (Protective, Damage and OXY) were evaluated.ResultsPatients were divided into: stabile angina pectoris (AP) (n=22), AMI with: ST-segment elevation (STEMI) (n=93), non-obstructive coronary arteries (MINOCA) (n=7), blood vessel rupture (n=6) in three time points, and compared to with 84 healthy subjects. Telomerase activity was significantly higher in all CAD sub-groups compared to the control group [AP=0.373 (0.355-0.386), STEMI=0.375 (0.349-0.395), MINOCA=0.391 (0.366-0.401), blood vessel rupture=0.360 (0.352-0.385) vs CG=0.069 (0.061-0.081), p=0.000], while telomeres were significantly shorter in STEMI, MINOCA and blood vessel rupture compared to the control group [STEMI=1.179 (0.931-1.376), MINOCA=1.026 (0.951-1.070), blood vessel rupture=1.089 (0.842-1.173) vs CG=1.329 (1.096-1.624), p=0.030]. Values of OXY score were significantly higher in STEMI and MINOCA patients compared to control group and AP patients [5.83 (4.55-7.54) and 10.28 (9.19-10.72) vs 4.94 (3.29-6.18) and 4.18 (2.58-4.86), p=0.000]. Longer telomeres and higher telomerase activity were found in thromboaspirates, compared to peripheral blood leukocytes in the same patients [1.25 (1.01 - 1.84) vs 1.18 (0.909 - 1.516), p=0.036; and 0.366 (0.367 - 0.379) vs 0.366 (0.367 - 0.379), p=0.000, respectively]. Telomere length and telomerase activity had good diagnostic ability to separate STEMI patients from controls.ConclusionsLeukocyte telomere length and telomerase activity can differentiate CAD patients from healthy persons, and relate CAD to oxidative stress.

Publisher

Termedia Sp. z.o.o.

Subject

General Medicine

Link

https://www.archivesofmedicalscience.com/pdf-136074-64289

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